Pycnogenol is a patented formulation of Pine Bark Extract of a tree known as Pinus pinaster. Studies have shown that Pycnogenol has powerful antioxidant activity and may reduce markers of inflammation . Pycnogenol is used for treating circulation problems, allergies, asthma, ringing in the ears, high blood pressure, muscle soreness, pain, osteoarthritis, diabetes, attention deficit-hyperactivity disorder (ADHD), a disease of the female reproductive system called endometriosis, menopausal symptoms, painful menstrual periods, erectile dysfunction (ED), and an eye disease called retinopathy.